The Missouri Research Park is the result of a vision of a technology corridor and has been the catalyst for high-tech development along the I-64 corridor in St. Charles County. Major corporations have followed the trend and are clustering near the Missouri Research Park.

• MasterCard International built its global technology center at WingHaven, a 1,000-acre development which includes homes, apartments, office buildings, research facilities, day-care center, golf course and a wellness center.
• WorldCom built a 300,000-square-foot campus directly across I-64.
• Citibank has developed a 500,000-square-foot building across I-64
• The corridor has been zoned "high tech" by local municipalities and the county

Owned and managed by the University of Missouri the Missouri Research Park officially opened in 1985. Today, more than 180 acres of land in the park are developed for high-tech and research facilities, and 15 tenant companies and two federal agencies employ approximately 2,000 people within the park.

The University of Missouri has established Protective Covenants to guide the development of this university-affiliated research and technology park.